Article

BMAL1-HIF2α heterodimers contribute to ccRCC

2024-07-16

Abstract excerpt

<title>Abstract</title> <p>Circadian disruption enhances cancer risk, and many tumors exhibit disordered circadian gene expression. We show rhythmic gene expression is unexpectedly robust in clear cell renal cell carcinoma (ccRCC). Furthermore, the clock gene BMAL1 is higher in ccRCC than in healthy kidneys, unlike in other tumor types. BMAL1 is closely related to ARNT, and we show that BMAL1-HIF2α regulates a su...

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Literature Corpus work: 834137c2-b81f-51e3-97eb-83c73dcc754f
DOI: 10.21203/rs.3.rs-4651047/v1

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