Article

Mice Bearing the Eµ- <i>myc</i> and Eµ- <i>pim</i> -l Transgenes Develop Pre-B-Cell Leukemia Prenatally

1991-02-01

Abstract excerpt

Previously, it has been shown that E mu-pim-1 transgenic mice are predisposed to T-cell lymphomas, whereas E mu-myc transgenic mice are predisposed to pre-B-cell lymphomas. Here we show that double-transgenic E mu-myc E mu-pim-1 mice exhibit pre-B-cell leukemia in utero. Upon transplantation into recipient mice, embryo-derived double-transgenic leukemic cells frequently progressed to highly malignant monoclonal tu...

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Literature Corpus work: 832fd2dc-13ad-5173-836e-678548c30db5
DOI: 10.1128/mcb.11.2.1176-1179.1991

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Mice Bearing the Eµ- <i>myc</i> and Eµ- <i>pim</i> -l Transgenes Develop Pre-B-Cell Leukemia PrenatallyDOI 10.1128/mcb.11.2.1176-1179.1991Read

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