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Article

mTOR signalling mediates the spinal osteoblast pathotype at the curve apex in adolescent idiopathic scoliosis

2026-02-22

Abstract excerpt

<title>Abstract</title> <p> Adolescent idiopathic scoliosis (AIS) is associated with dysregulated bone remodelling, yet the molecular underpinnings remain unclear. To investigate site-specific osteoblast phenotypes at the spinal curve apex, we performed bulk RNA sequencing on primary matched osteoblasts isolated from the convex, concave, and non-curved regions of AIS patients. Principal component analysis reveal...

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Literature Corpus work
82b398d0-71c9-5b04-867a-b21d789ae947
DOI
10.21203/rs.3.rs-8911774/v1
Open publication

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mTOR signalling mediates the spinal osteoblast pathotype at the curve apex in adolescent idiopathic scoliosisDOI 10.21203/rs.3.rs-8911774/v1
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