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Article

Genetics Meets Metabolism: Decoding Their Role in Idiopathic Scoliosis.

Studies in health technology and informatics - 15 Jun 2026

Moldovan Florina

Abstract excerpt

Adolescent Idiopathic Scoliosis (AIS) is increasingly recognized as a multisystem disorder arising from the interplay between genetic susceptibility, metabolic dysregulation, and impaired mechanobiological signaling. Recent genomic studies highlight defects in ciliary genes, implicating disrupted ciliary structure and signaling in altered spinal growth. Concurrently, metabolic disturbances including pubertal...

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PMID: 42290413
DOI: 10.3233/SHTI260736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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