Article

Post-translational Regulation of the PI3K/Akt/mTOR–Autophagy Axis in Osteoblast Differentiation and Its Polypharmacological Targeting by Eupolyphaga sinensis

2026-08-13

Abstract excerpt

<title>Abstract</title> <p> Fracture healing is a complex biological process in which osteoblast differentiation plays a central role, yet the molecular mechanisms governing this process remain incompletely understood. The PI3K/Akt/mTOR signaling pathway and autophagy are critical regulators of osteoblast function, but the relationship between their transcriptional and post-translational regulation during human...

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Literature Corpus work: 7ed84e6b-ac2e-5dc7-bbc4-fa76f5ebfcb6
DOI: 10.21203/rs.3.rs-10564122/v1

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