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Pharmacokinetics and <i>In vivo</i> Efficacy of Epetraborole against <i>Burkholderia pseudomallei</i>

2025-07-14

Abstract excerpt

Melioidosis, caused by Burkholderia pseudomallei , remains a major therapeutic challenge due to high relapse rates and intrinsic antibiotic resistance. Epetraborole (EBO), a leucyl-tRNA synthetase inhibitor, represents a novel therapeutic approach with a distinct mechanism of action compared to standard-of-care antibiotics. Preclinical studies included MIC determination, pharmacokinetic (PK) profiling, dose range...

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Literature Corpus work
82343527-8d55-57cc-b1d7-bd25b21744d4
DOI
10.1101/2025.07.10.664055
Open publication

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