Article

Reliable Detection of SGLT2 Protein through Knockout-based Antibody Characterization and Optimized Procedures

2025-09-01

Abstract excerpt

<h4>Introduction</h4> Sodium-glucose cotransporter 2 (SGLT2) is a key mediator of renal glucose reabsorption. Its pharmacological inhibition exerts cardio- and reno-protective benefits. Despite widespread clinical interest, reliable detection of SGLT2 protein remains challenging due to concerns regarding the specificity of available antibodies. <h4>Methods</h4> This study assessed the specificity of eight commer...

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Literature Corpus work: 820ae22d-2094-51c1-9977-4efa458a8d66
DOI: 10.1101/2025.08.31.672288

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