Article

Cyclic gallium-68 labeled peptides for specific detection of human angiotensin-converting enzyme 2

2020-12-16

Abstract excerpt

In this study, we developed ACE2-specific, peptide-derived 68 Ga-labeled radiotracers, motivated by the hypotheses that (1) ACE2 is an important determinant of SARS-CoV-2 susceptibility, and (2) that modulation of ACE2 in COVID-19 drives severe organ injury. <h4>Methods</h4> A series of NOTA-conjugated peptides derived from the known ACE2 inhibitor DX600 were synthesized, with variable linker identity. Since DX...

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Identifiers and source

Literature Corpus work: 81e881df-0023-5b5f-aa42-4f82d58aedd3
DOI: 10.1101/2020.12.15.412809

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