A Mathematical Model of the Phosphoinositide Pathway

Abstract excerpt

<h4>ABSTRACT</h4> Phosphoinositides are signaling lipids that constitute a complex network regulating many cellular processes. We propose a computational model that accounts for all known species of phosphoinositides in the plasma membrane of mammalian cells. The model replicates the steady-state of the phosphoinositide pathway and most known dynamic phenomena. Furthermore, sensitivity analysis demonstrates model...

Topics

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• Cystic Fibrosis Research Advances
• Ion Transport and Channel Regulation
• MAP Kinase Signaling System
• Models, Biological
• Mutation
• Neonatal Respiratory Health Research
• Phosphatidylinositol 3-Kinases
• Signal Transduction

Identifiers and source

Literature Corpus work

81b9a850-4b39-530d-94aa-ea1f8496852e

DOI

10.1101/182634