Article

Methamphetamine enhances HIV-induced aberrant proliferation of neural progenitor cells via the FOXO3-mediated mechanism

2020-11-18

Abstract excerpt

<title>Abstract</title> <p>BackgroundMaintaining an intact pool of neural progenitor cells (NPCs) is crucial for generating new and functionally active neurons. As intrinsic and microenvironments tightly control developmental processes of adult neurogenesis, Methamphetamine (METH) and HIV-1-mediated impairment of the blood-brain barrier and development of neuroinflammation may induce alterations in functions of N...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 81aaebc8-19c6-5ad4-bfbb-4a85f849370d
DOI: 10.21203/rs.3.rs-107347/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Methamphetamine enhances HIV-induced aberrant proliferation of neural progenitor cells via the FOXO3-mediated mechanismDOI 10.21203/rs.3.rs-107347/v1Read

Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells drives neuroinflammation in SIV-infected rhesus macaquesSemantic proximity Read

Investigation of CNS damage following HIV infection and methamphetamine exposure using human iPSC-derived microglia and 3D cerebral assembloid modelsSemantic proximity Read

Brain Transcriptome Analysis Reveals Exercise Improves Methamphetamine-Induced Impairments in Mouse Learning and Memory AbilitiesSemantic proximity Read

Methamphetamine Facilitates HIV Infection of Human Monocytes Through Inhibiting Cellular Viral Restriction FactorsSemantic proximity Read

Implication of the Autophagy-Related Protein Beclin1 in the Regulation of EcoHIV Replication and Inflammatory ResponsesSemantic proximity Read

Hippocampal single-cell RNA Atlas of chronic methamphetamine abuse-induced cognitive decline in miceSemantic proximity Read

TLR3 Activation of Microglia-Containing Cerebral Organoid Induces Antiviral Factors against HIV-1 InfectionSemantic proximity Read

STAT1-Mediated Regulation of IL-17A/CEBPB/NF-κB Axis in HIV-1 Infected Human Cerebral Organoids Reveals Therapeutic Targets for NeuroprotectionSemantic proximity Read

NLRP3 inflammasome-related microglial pyroptosis in EcoHIV infected miceSemantic proximity Read

Opioid-induced immunosuppression of brain myeloid cells in SIV-infected rhesus macaquesSemantic proximity Read

Retroviral Infection of Human Neurospheres and Use of Stem Cell EVs to Repair Cellular DamageSemantic proximity Read

“UnPAKing” Human Immunodeficiency Virus (HIV) Replication: Using Small Interfering RNA Screening To Identify Novel Cofactors and Elucidate the Role of Group I PAKs in HIV InfectionSemantic proximity Read