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Temporal dysregulation of PPARG-PRKAG2 co-expression in gray matter: Implications for cognitive decline and intervention targets in type 2 diabetes

2025-10-22

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Type 2 diabetes mellitus (T2DM) is associated with increased risk for cognitive decline and diagnosis of Alzheimer’s disease (AD). The mechanisms of T2DM related dementia remain unclear. <bold>Methods:</bold> Brain magnetic resonance imaging was retrospectively obtained for 1,802 adults (age 66 +/- 9 years, 47% male) of whom N = 271 had T2DM. We applied an...

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Literature Corpus work
813d3791-4a5d-5c71-ae86-8d823aaba795
DOI
10.21203/rs.3.rs-7907793/v1
Open publication

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Temporal dysregulation of PPARG-PRKAG2 co-expression in gray matter: Implications for cognitive decline and intervention targets in type 2 diabetesDOI 10.21203/rs.3.rs-7907793/v1
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