Article

Capturing the Differences between Humoral Immunity in the Normal and Tumor Environments from Repertoire-Seq of B-Cell Receptors Using Supervised Machine Learning

2017-09-11

Abstract excerpt

<h4>ABSTRACT</h4> The recent success of immunotherapy in treating tumors has attracted increasing interest in research related to the adaptive immune system in the tumor microenvironment. Recent advances in next-generation sequencing technology enabled the sequencing of whole T-cell receptors (TCRs) and B-cell receptors (BCRs)/immunoglobulins (Igs) in the tumor microenvironment. Since BCRs/Igs in tumor tissues ha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8117c2c8-4a2f-5fd3-9b14-2e7a7ae21a05
DOI: 10.1101/187120

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Capturing the Differences between Humoral Immunity in the Normal and Tumor Environments from Repertoire-Seq of B-Cell Receptors Using Supervised Machine LearningDOI 10.1101/187120Read

The Diagnostic, Prognostic, and Therapeutic Potential of Adaptive Immune Receptor Repertoire Profiling in CancerSemantic proximity Read

Detection of disease-specific signatures in B cell repertoires of lymphomas using machine learningSemantic proximity Read

Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligenceSemantic proximity Read

Characteristics of profiling the peripheral blood T‐cell receptor repertoire in patients with diffuse large B-cell lymphomaSemantic proximity Read

Human TCR repertoire in cancerSemantic proximity Read

Quantitative T cell repertoire analysis by deep cDNA sequencing of T cell receptor α and β chains using next-generation sequencing (NGS)Semantic proximity Read

Systematic identification of cancer-specific MHC-binding peptides with RAVENSemantic proximity Read

B cell receptor (BCR) diversity and differential CDR3s usage as potential immune indictors of diffuse large B cell lymphoma (DLBCL) Running title: Vital roles of BCR traits in DLBCLSemantic proximity Read

Immunogenetic Profiling for Gastric Cancers Identifies Sulfated Glycosaminoglycans as Major and Functional B Cell Antigens in Human MalignanciesSemantic proximity Read

Characteristics of profiling the peripheral blood T-cell receptor β-chain repertoire in gastric cancerSemantic proximity Read

Establishment of a typing model for diffuse large B-cell lymphoma based on B-cell receptor repertoire sequencing.Semantic proximity Read

Rigorous benchmarking of T cell receptor repertoire profiling methods for cancer RNA sequencingSemantic proximity Read