Article

Gene Profiling of Toll-like Receptor Signaling Pathways in Neutrophils of Patients With Acute-on-chronic Liver Failure

2021-06-09

Abstract excerpt

<h4>Objectives: </h4> Toll-like receptors (TLRs) of neutrophils play a crucial role in detecting pathogens and organ/tissue injury in acute-on-chronic liver failure (ACLF). However, little is known about the exact mechanisms and the potential signaling pathways. The aim of this study was to investigate alterations of TLR signaling pathways in neutrophils of ACLF patients. <h4>Methods: </h4> Twenty-seven patients w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8114209c-c79f-5177-86d8-b6ebbf2eb291
DOI: 10.21203/rs.3.rs-541965/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene Profiling of Toll-like Receptor Signaling Pathways in Neutrophils of Patients With Acute-on-chronic Liver FailureDOI 10.21203/rs.3.rs-541965/v1Read

Inflammatory Signature in Acute-on-Chronic Liver Failure Includes Increased Expression of Neutrophil Specific Genes ELANE, MPO and CD177 Running Title: Neutrophil Transcriptomics in ACLFSemantic proximity Read

Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure.Semantic proximity Read

Circulating Neutrophil Dysfunction in HBV-Related Acute-on-Chronic Liver Failure.Semantic proximity Read

Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in ratsSemantic proximity Read

Inflammatory signature in acute-on-chronic liver failure includes increased expression of granulocyte genes ELANE, MPO and CD177Semantic proximity Read

Identification of oxidative stress-related biomarkers associated with the development of acute-on-chronic liver failure using bioinformaticsSemantic proximity Read

Circulating Lipids Predict Mortality and Drive Immune Gene Regulation in Acute-on-Chronic Liver FailureSemantic proximity Read

Increased hepatic expression of TLR2 and TLR4 in the hepatic inflammation-fibrosis-carcinoma sequenceSemantic proximity Read

Characteristics of systemic inflammation in hepatitis B-precipitated ACLF: Differentiate it from No-ACLF.Semantic proximity Read

Pattern Recognition Receptors: Significance of Expression in the LiverSemantic proximity Read

Alcohol Responsive Genes in the Neutrophils of Acute-On-Chronic Liver Failure Reveal Modulation of Intracellular Calcium, ROS, and PhagocytosisSemantic proximity Read

Role of Toll-like receptors in liver health and diseaseSemantic proximity Read