Article

Co-Cultivation Assays for Detecting Infectious Human-Tropic Porcine Endogenous Retrovirus (PERV)

2025-06-16

Abstract excerpt

Porcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs. Since they can be released as infectious virus particles capable of infecting human cells in vitro, they pose a potential risk for xenotransplantation involving pig cells or organs. To assess whether pigs produce infectious human-tropic viruses, infection assays with human cells are required. There are three main assays: First, inc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 80e0a61b-f5fa-5ec6-9e61-2dd8382dac6f
DOI: 10.20944/preprints202506.1087.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Co-Cultivation Assays for Detecting Infectious Human-Tropic Porcine Endogenous Retrovirus (PERV)DOI 10.20944/preprints202506.1087.v1Read

How Active Are Porcine Endogenous Retroviruses (PERVs)?Semantic proximity Read

Comparison of porcine endogenous retroviruses infectious potential in supernatants of producer cells and in coculturesSemantic proximity Read

Chapter 5: Strategies to prevent transmission of porcine endogenous retrovirusesSemantic proximity Read

Infection Barriers to Successful Xenotransplantation Focusing on Porcine Endogenous RetrovirusesSemantic proximity Read

Characterisation of a human cell-adapted porcine endogenous retrovirus PERV-A/C.Semantic proximity Read

Porcine Endogenous Retroviruses in Xenotransplantation—Molecular AspectsSemantic proximity Read

Xenotransplantation and pig endogenous retrovirusesSemantic proximity Read

Screening pigs for xenotransplantation: prevalence and expression of porcine endogenous retroviruses in G öttingen minipigsSemantic proximity Read

Infection studies on human cell lines with porcine circovirus type 1 and porcine circovirus type 2Semantic proximity Read

Productive infection of primary human endothelial cells by pig endogenous retrovirus (PERV)Semantic proximity Read

Pig endogenous retroviruses and xenotransplantationSemantic proximity Read

A Comprehensive Strategy for Screening for Xenotransplantation-Relevant Viruses in a Second Isolated Population of Göttingen MinipigsSemantic proximity Read