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Article

Comparison of porcine endogenous retroviruses infectious potential in supernatants of producer cells and in cocultures

21 Jan 2014

Abstract excerpt

BACKGROUND: Porcine endogenous retroviruses (PERV) pose a zoonotic risk potential in pig-to-human xenotransplantation given that PERV capacity to infect different human cell lines in vitro has been clearly shown in the past. However, PERV infectious potential for human peripheral blood mononuclear cells (huPBMC) has been also demonstrated, albeit with controversial results. As productive PERV infection of huPBMC...

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PMID: 24447212
DOI: 10.1111/xen.12081

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