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Article

Screening pigs for xenotransplantation: prevalence and expression of porcine endogenous retroviruses in G öttingen minipigs

2 Apr 2013

Abstract excerpt

BACKGROUND: To establish the safety of xenotransplantation when cells, tissues, or organs of pigs are used, an effective screening for potential zoonotic microorganisms has to be performed. In doing so, special attendance has to be paid to porcine endogenous retroviruses (PERVs) that are widely distributed as proviruses in the genome of pigs. PERV-A and PERV-B are present in all pigs, they infect human cells in...

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PMID: 23551867
DOI: 10.1111/xen.12032

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