Back to search

Article

The miR-19b-3p/MAP2K3/STAT3 Feedback Loop Regulates Cell Proliferation and Invasion in Esophageal Squamous Cell Carcinoma

2020-07-23

Abstract excerpt

<h4>Background: </h4> Esophageal squamous cell carcinoma (ESCC) remains one of the most refractory malignancies worldwide. MAP2K3 has been reported to play an important role in tumor progression. However, whether MAP2K3 also affects ESCC remains to be determined. <h4>Method: </h4> We used a CRISPR/Cas9 kinome screen to identify the genes related to ESCC cell survival. The MAP2K3 expression was detected in ESCC tis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
80bbd8a0-4df8-5113-b34a-6ffde254e632
DOI
10.21203/rs.3.rs-46772/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The miR-19b-3p/MAP2K3/STAT3 Feedback Loop Regulates Cell Proliferation and Invasion in Esophageal Squamous Cell CarcinomaDOI 10.21203/rs.3.rs-46772/v1
STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinomaSemantic proximity
NEK2 Promotes the Migration, Invasion, Proliferation and Drug Resistance of ESCC Through the E2F1-IGF2 PathwaySemantic proximity
CDKN3 promotes cell proliferation, invasion and migration by activating the AKT signaling pathway in esophageal squamous cell carcinomaSemantic proximity
KRT17 Facilitates Proliferation, Migration and Invasion in Esophageal Squamous Cell Carcinoma by Regulating mTOR/S6K1 pathwaySemantic proximity
The oncogene EIF3c promotes esophageal squamous cell carcinoma tumorigenesis by inhibiting cell proliferation and inducing cell apoptosisSemantic proximity
Upregulation of KIF18B facilitates malignant phenotype of esophageal squamous cell carcinoma by activating CDCA8/mTORC1 pathway.Semantic proximity
Investigating DOCK9 as a Potential Prognostic Marker: Implications for Angiogenesis and Immunity in Esophageal Squamous Cell CarcinomaSemantic proximity
Anlotinib inhibits the development of esophageal squamous cell carcinoma by regulating the PI3K/AKT signaling pathwaySemantic proximity
Bioinformatics and experimental validation of an AURKA/TPX2 axis as a potential target in esophageal squamous cell carcinomaSemantic proximity
Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review)Semantic proximity
SOX12 contributes to the activation of the JAK2/STAT3 pathway and malignant transformation of esophageal squamous cell carcinomaSemantic proximity
Molecular mechanism and clinical significance of Notch3 negative regulation of BRD4 on the growth and survival of esophageal squamous cell carcinomaSemantic proximity
Select a neighboring publication to make it the new centre.