Article

Protein-truncating and rare missense variants in<i>ATM</i>and<i>CHEK2</i>and associations with cancer in UK Biobank whole-exome sequenced data

2024-07-03

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> Deleterious germline variants in ATM and CHEK2 have been associated with a moderately increased risk of breast cancer. Risks for other cancers remain unclear, and require further investigation. <h4>Methods</h4> Cancer associations for coding variants in ATM and CHEK2 were evaluated using whole-exome sequenced data from UK Biobank linked to cancer registration data (348,488 part...

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Literature Corpus work: 80a2194d-4657-5836-900d-22138024b8e7
DOI: 10.1101/2024.07.01.24309756

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