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A Lactylation-Related Radiosensitivity Index Predicts Differential Radiotherapy Benefit in Head and Neck Squamous Cell Carcinoma

2026-04-21

Abstract excerpt

<title>Abstract</title> <p>Radiotherapy (RT) is integral to the management of head and neck squamous cell carcinoma (HNSCC), yet no validated biomarker exists to predict which patients benefit most. Lactylation, a metabolic post-translational modification, has been linked to DNA damage repair (DDR) and therapeutic resistance, but no lactylation-based radiosensitivity biomarker has been established in HNSCC. Here,...

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Literature Corpus work
80882dbe-86a4-52c8-af51-3598bbb2d43e
DOI
10.21203/rs.3.rs-9250884/v1
Open publication

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A Lactylation-Related Radiosensitivity Index Predicts Differential Radiotherapy Benefit in Head and Neck Squamous Cell CarcinomaDOI 10.21203/rs.3.rs-9250884/v1
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