Article

Comprehensive genomic profiling-guided treatment selection in appendiceal adenocarcinoma with discordant mismatch repair findings: a case report and literature review

2026-08-28

Abstract excerpt

<title>Abstract</title> <p> Background Appendiceal adenocarcinoma is rare, and systemic treatment is often extrapolated from colorectal cancer. Discordance between mismatch repair (MMR) immunohistochemistry and microsatellite instability (MSI) or tumor mutational burden (TMB) testing can complicate treatment selection, particularly in rare gastrointestinal cancers. We report a case in which comprehensive genomi...

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Literature Corpus work: 80776a09-520e-594c-9a92-d34137cdba1e
DOI: 10.21203/rs.3.rs-10434247/v1

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