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Article

A clinically actionable stratification of bullous pemphigoid using a disease activity score reveals a targetable inflammatory endotype.

The British journal of dermatology - 17 Jul 2026

Cao Zhiqiang, Kong Shuzhen, Ye Jianqiao, Hu Weihong, Zhu Yanyan, Tao Yueran, Che Delu, Yuan Baobao, Gui Yanhong, Raap Ulrike, Geng Songmei, Peng Bin

Abstract excerpt

BACKGROUND: Bullous pemphigoid (BP) exhibits significant clinical heterogeneity. The molecular drivers underlying these distinct phenotypes remain poorly understood, hindering the development of precision medicine approaches. OBJECTIVES: To correlate clinical phenotypes, defined by the Bullous Pemphigoid Disease Area Index (BPDAI), with molecular endotypes using serum proteomic profiling. METHODS: This cohort...

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PMID: 42019951
DOI: 10.1093/bjd/ljag156

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