Back to search

Article

The Impact of OATP Variants on the Side Effects of Direct-Acting Antivirals in Hepatitis C Patients

2024-07-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Organic anion-transporting polypeptides (OATPs) are responsible for the cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple tissues. The aim of our study was to determine whether variations in OATP1B1 and OATP1B3 affect the side effects experienced by hepatitis C patients treated with direct-acting antivirals (DAAs). <bold>Method...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8066158c-522b-5c32-8d52-2d6462c19cf1
DOI
10.21203/rs.3.rs-4578225/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The Impact of OATP Variants on the Side Effects of Direct-Acting Antivirals in Hepatitis C PatientsDOI 10.21203/rs.3.rs-4578225/v1
Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions.Semantic proximity
An Investigation of the Side Effects, Patient Feedback, and Physiological Changes Associated with Direct-Acting Antiviral Therapy for Hepatitis C.Semantic proximity
Interactions of Anti-COVID-19 Drug Candidates With Hepatic Transporters May Cause Liver Toxicity and Affect Drug MetabolismSemantic proximity
The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized miceSemantic proximity
Safety, pharmacokinetics and pharmacogenetics of a single ascending dose of pradefovir, a novel liver-targeting, anti-hepatitis B virus drug, in healthy Chinese subjects.Semantic proximity
Concomitant use of sorafenib with ombitasvir/paritaprevir/ritonavir and dasabuvir: Effectiveness and safety in clinical practice.Semantic proximity
Association between alanine aminotransferase elevation and UGT1A1*6 polymorphisms in daclatasvir and asunaprevir combination therapy for chronic hepatitis C.Semantic proximity
Impact of Lenvatinib on OATP1B Activity in Patients with Hepatocellular CarcinomaSemantic proximity
ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients.Semantic proximity
Cardiac toxicity associated with pharmacokinetic drug–drug interaction between crizotinib and sofosbuvir/velpatasvir: a case reportSemantic proximity
Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect drug metabolismSemantic proximity
Select a neighboring publication to make it the new centre.