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Determinants of functional burden pleiotropy and gene dosage responses across human traits

2026-08-14

Abstract excerpt

Pleiotropic and monotonic effects of gene dosage are central to understanding comorbidities in developmental pediatric and psychiatric disorders, yet the underlying biological processes are not well characterized. Here we develop a functional burden analysis to investigate the association of all protein-coding copy-number variants, genome-wide, with 43 complex traits in approximately 500,000 UK Biobank participant...

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Literature Corpus work
8058842e-a322-57da-ade2-e7378752eec4
DOI
10.1038/s41467-026-76676-0
Open publication

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Determinants of functional burden pleiotropy and gene dosage responses across human traitsDOI 10.1038/s41467-026-76676-0
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