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Article

Determinants of pleiotropy and monotonic gene dosage responses across human traits

2025-11-19

Abstract excerpt

<title>Abstract</title> <p>While pleiotropic effects of gene dosage are of particular relevance for comorbidities observed in the developmental pediatric and psychiatric clinic, the biological processes underlying such pleiotropy remain unknown. We developed a new functional burden analysis (FunBurd) to investigate all CNVs, genome-wide, beyond well-studied recurrent CNVs. In ~500,000 UK-Biobank participants, we...

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Literature Corpus work
cd788de2-5748-5b73-bacc-b6d01d72a279
DOI
10.21203/rs.3.rs-7547111/v1
Open publication

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Determinants of pleiotropy and monotonic gene dosage responses across human traitsDOI 10.21203/rs.3.rs-7547111/v1
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