Article

A rare human <i>TNFAIP3</i> variant reveals how A20 abundance is regulated by TAX1BP1

2026-03-26

Abstract excerpt

Variants in TNFAIP3 (encoding A20) are among the most consistent non-MHC genetic associations with human autoimmune disease. Moreover, TNFAIP3 haploinsufficiency confers an autosomal dominant autoinflammatory and autoimmune disease. Whilst these findings strongly suggest that quantitative changes in A20 predispose to pathology, there is currently no evidence that post-transcriptional modifications regulate A20 a...

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Literature Corpus work: 2fff70b1-f0f8-5c50-856d-d2dfa9a556e7
DOI: 10.64898/2026.03.25.714162

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