Article

Targeting RET Kinase in Neuroendocrine Prostate Cancer

2019-04-29

Abstract excerpt

Increased treatment of metastatic castration resistant prostate cancer (mCRPC) with second-generation anti-androgen therapies (ADT) has coincided with a greater incidence of lethal, aggressive variant prostate cancer (AVPC) tumors that have lost androgen receptor (AR) signaling. AVPC tumors may also express neuroendocrine markers, termed neuroendocrine prostate cancer (NEPC). Recent evidence suggests kinase signal...

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Literature Corpus work: 80338a14-8378-5cbc-b6f4-3b6fc2fa8a51
DOI: 10.1101/622415

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