Article

Functionality of BRCA1 supports the survival of prostate cancer cells during the development of castration resistance

2024-06-23

Abstract excerpt

Androgen deprivation therapy (ADT; castration) is the main treatment option for metastatic prostate cancer (PCa), but eventually, castration-resistant prostate cancer (CRPC) develops with no curative treatments. In CRPC, more than 20% of men carry mutations in DNA damage response (DDR) genes, including BRCA1/2. In this study, we elucidated the prostate tissue-specific functional role of BRCA1 protein. Our results...

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Literature Corpus work: 7fe24e96-88a6-592c-bbae-49c33e0e04a0
DOI: 10.1101/2024.06.19.599365

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