Article

ralphi: a deep reinforcement learning framework for haplotype assembly

2025-02-21

Abstract excerpt

Haplotype assembly is the problem of reconstructing the combination of alleles on the maternally and paternally inherited chromosome copies. Individual haplotypes are essential to our understanding of how combinations of different variants impact phenotype. In this work, we focus on read-based haplotype assembly of individual diploid genomes, which reconstructs the two haplotypes directly from read alignments at v...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7fc4771e-fe0b-5813-ad5f-cb00b83cf967
DOI: 10.1101/2025.02.17.638151

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ralphi: a deep reinforcement learning framework for haplotype assemblyDOI 10.1101/2025.02.17.638151Read

Optimal Haplotype Assembly from High-Throughput Mate-Pair ReadsSemantic proximity Read

Generative Haplotype Prediction Outperforms Statistical Methods for Small Variant Detection in NGS DataSemantic proximity Read

WhatsHap: Weighted Haplotype Assembly for Future-Generation Sequencing Reads.Semantic proximity Read

A Step Towards a Reinforcement Learning De Novo Genome AssemblerSemantic proximity Read

ARHap: Association Rule Haplotype Phasing.Semantic proximity Read

Haplotype-aware sequence alignment to pangenome graphsSemantic proximity Read

Automatic Generation of Model Sequences for Complex Regions in Assembly GraphsSemantic proximity Read

Sparse Tensor Decomposition for Haplotype Assembly of Diploids and Polyploids.Semantic proximity Read

A highly accurate heuristic algorithm for the haplotype assembly problem.Semantic proximity Read

Improved haplotype assembly using Xor genotypes.Semantic proximity Read

DeepHapNet: a haplotype assembly method based on RetNet and deep spectral clustering.Semantic proximity Read

HapCol: accurate and memory-efficient haplotype assembly from long reads.Semantic proximity Read