Article

Spatial biomarker-driven deep learning model via digital pathology predicts response to PI3K inhibitor buparlisib in head and neck squamous cell carcinoma

2025-10-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Buparlisib, a pan-class I PI3K inhibitor, combined with paclitaxel, demonstrated improved survival in the BERIL-1 trial for patients with recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). However, predictive biomarkers of benefit remain undefined. We evaluated spatial biomarkers derived from hematoxylin and eosin (H&E) images using artificial intelligenc...

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Literature Corpus work: 7f8b1a92-94ef-57c9-aace-e516225bae58
DOI: 10.1101/2025.10.09.25337502

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