Article

Age-dependent chromosomal instability in osteosarcoma: younger patients exhibit paradoxically higher genomic damage

2026-01-16

Abstract excerpt

<title>Abstract</title> <p>Osteosarcoma is an aggressive bone malignancy with peak incidence during adolescence and a secondary peak in older adults. While the disease is characterized by extreme chromosomal instability, the relationship between patient age and genomic damage has not been systematically quantified. Here, using two independent cohorts totaling 589 osteosarcoma samples, we demonstrate a paradoxical...

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Literature Corpus work: 7f8ab358-1466-58f3-9207-7bb648e73d9b
DOI: 10.21203/rs.3.rs-8554974/v1

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