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Article

Molecular profiling of osteosarcoma in children and adolescents from different age groups using a next-generation sequencing panel.

Cancer genetics - 1 Nov 2021

Guimarães G M, Tesser-Gamba F, Petrilli A S, Donato-Macedo C R P, Alves M T S, de Lima F T, Garcia-Filho R J, Oliveira R, Toledo S R C

Abstract excerpt

Osteosarcoma (OS) is a malignant bone tumor, with a peak of incidence in the second decade of life and possibly associated with the presence of germline mutations. Besides, clinicians have pointed to a second, rarer group of patients that develops OS before 10 years old. Here we access, through next-generation sequencing (NGS) strategy, the genetic alterations present in OS and blood samples from patients...

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Identifiers

PMID: 34666222
DOI: 10.1016/j.cancergen.2021.10.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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