Article

SPADIS: An Algorithm for Selecting Predictive and Diverse SNPs in GWAS

2018-01-30

Abstract excerpt

Phenotypic heritability of complex traits and diseases is seldom explained by individual genetic variants. Algorithms that select SNPs which are close and connected on a biological network have been successful in finding biologically-interpretable and predictive loci. However, we argue that the connectedness constraint favors selecting redundant features that affect similar biological processes and therefore does...

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Literature Corpus work: 7f7f0682-aeaf-52b3-a72f-0607bf319cb1
DOI: 10.1101/256677

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