Article

<i>Bacteroides fragilis</i> modulates gut microbiome community composition, frontal cortex gene expression, and fecal and frontal cortex metabolites in a mouse model of Alzheimer’s disease pathologies

2026-05-30

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disease and the leading cause of dementia among elderly. Gut microbiome alterations precede pathogenesis and may affect disease outcomes. We evaluated the role of Bacteroides fragilis in triple transgenic mice modeling AD pathologies (3xTg-AD) and wild-type controls (WT). Subsets of 3xTg-AD and WT mice were longitudinally treated with B. fragilis or sterile vehicle...

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Literature Corpus work: 5ea9c1b7-f7f8-56cc-8690-2717af2e4500
DOI: 10.64898/2026.05.29.728805

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