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Article

Structural signature of the G719S-T790M double mutation in the EGFR kinase domain and its response to inhibitors.

Scientific reports - 5 Aug 2014

Doss George Priya C, Rajith B, Chakraborty Chiranjib, NagaSundaram N, Ali Shabana Kouser, Zhu Hailong

Abstract excerpt

Some individuals with non-small-cell lung cancer (NSCLC) benefit from therapies targeting epidermal growth factor receptor (EGFR), and the characterization of a new mechanism of resistance to the EGFR-specific antibody gefitinib will provide valuable insight into how therapeutic strategies might be designed to overcome this particular resistance mechanism. The G719S and T790M mutations and their combination were...

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Identifiers

PMID: 25091415
DOI: 10.1038/srep05868
PMCID: PMC4121614

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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