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Article

Chemotherapy Drug Response to the L858R-induced Conformational Change of EGFR Activation Loop in Lung Cancer.

Molecular informatics - 1 Oct 2016

Ding Xi, Liu Xingcai, Song Xiaoyun, Yao Jun

Abstract excerpt

Oncogenic L858R mutation of human epidermal growth factor receptor (EGFR) confers constitutive activation to the kinase and is frequently observed in the pathological process of metastatic lung cancer. Selective inhibition of EGFRL858R mutant over wild-type EGFR (EGFRWT ) has been established as an attractive target for cancer chemotherapy. Here, we performed long-term molecular dynamics (MD) simulations to...

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PMID: 27643705
DOI: 10.1002/minf.201600088

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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