Article

Not So Rare After All: Rethinking Hereditary Transthyretin Amyloidosis

2026-05-13

Abstract excerpt

<h4>Background: </h4> Transthyretin amyloidosis (ATTR) is a rare, often underdiagnosed and undertreated, autosomal dominantly inherited, progressive disease that affects multiple systems of the body. It results from the extracellular accumulation of misfolded transthyretin (TTR) protein as insoluble amyloid fibrils, predominantly causing cardiomyopathy, polyneuropathy or mixed phenotypes. It can occur in a heredit...

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Literature Corpus work: 6517632c-b424-5c01-933f-d85a99f041d2
DOI: 10.20944/preprints202605.0819.v1

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