Article

Rapid Emergence of Resistance to Broad-Spectrum Direct Antimicrobial Activity of Avibactam

2024-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Avibactam (AVI) is a diazabicyclooctane (DBO) β-lactamase inhibitor used clinically in combination with ceftazidime. At concentrations higher than those typically achieved in vivo , it also has broad-spectrum direct antibacterial activity against Enterobacterales strains, including metallo-β-lactamase-producing isolates, mediated by inhibition of penicillin-binding protein 2 (PBP2). This activ...

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Literature Corpus work: 7ec65e16-90d2-55bc-9677-5f3804da7366
DOI: 10.1101/2024.09.25.615047

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