Article

A high-throughput, image-based assay to assess drug sensitivity of <i>Acanthamoeba castellanii</i> cysts

2025-06-06

Abstract excerpt

Pathogenic free-living amoebae (FLA) such as Acanthamoeba castellanii are present in soil and water worldwide. A. castellanii causes systemic infections with very high mortality rates, yet drugs specifically targeting this pathogen are not available. Methods to reliably generate and assay cysts, which drive infection recurrence and drug resistance, are unavailable in a high-throughput format suitable for drug sc...

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Literature Corpus work: 7e7dd423-fc50-52af-afed-995c4b66b569
DOI: 10.1101/2025.06.06.658337

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