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Novel Tetrazoles against Acanthamoeba castellanii Belonging to the T4 Genotype.

Chemotherapy - 1 Jan 2022

Wehelie Yassmin Isse, Khan Naveed Ahmed, Fatima Itrat, Anwar Areeba, Kanwal Kanwal, Khan Khalid M, Siddiqui Ruqaiyyah, Tong Yuh Koon, Anwar Ayaz

Abstract excerpt

BACKGROUND: Acanthamoeba castellanii is a pathogenic free-living amoeba responsible for blinding keratitis and fatal granulomatous amoebic encephalitis. However, treatments are not standardized but can involve the use of amidines, biguanides, and azoles. OBJECTIVES: The aim of this study was to synthesize a variety of synthetic tetrazole derivatives and test their activities against A. castellanii. METHODS: A...

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PMID: 34724675
DOI: 10.1159/000520585

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