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Red blood cells capture and deliver bacterial DNA to drive host responses during polymicrobial sepsis

12 Dec 2024

Abstract excerpt

Red blood cells (RBCs), traditionally recognized for their role in transporting oxygen, play a pivotal role in the body's immune response by expressing TLR9 and scavenging excess host cell-free DNA. DNA capture by RBCs leads to accelerated RBC clearance and triggers inflammation. Whether RBCs can also acquire microbial DNA during infections is unknown. Murine RBCs acquire microbial DNA in vitro, and bacterial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39666381
DOI: 10.1172/jci182127

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