Article

The stress-responsive protein REDD1 drives diabetic myocardial injury via activation of autophagy-dependent ferroptosis

2025-04-17

Abstract excerpt

Diabetic cardiomyopathy (DCM), a lethal cardiovascular complication of diabetes, lacks effective therapies. Regulated in development and DNA damage response 1 (REDD1), a stress-responsive gene implicated in diabetic pathologies, was investigated for its role in autophagy and ferroptosis during DCM progression. Diabetic mice (high-fat diet/streptozotocin-induced) and high glucose (HG)-exposed human AC16 cardiomyocy...

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Literature Corpus work: 2c6823d6-db8f-5cf4-876e-820b56cefe1d
DOI: 10.22541/au.174489134.49875039/v1

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