Advancing precision health discovery in a genetically diverse health system.

doi:10.1016/j.cell.2026.03.007

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Advancing precision health discovery in a genetically diverse health system.

Cell - 30 Apr 2026

Haas Roni, Margolis Michael P, Wei Angela, Yamaguchi Takafumi N, Feng Jeffrey, Tran Thai, Tozzo Veronica, Queen Katelyn J, Mootor Mohammed Faizal Eeman, Patil Vishakha, Broudy Michael E, Tung Paul, Alam Shafiul, Martinez Danielle B, Patel Yash, Caggiano Christa, Zeltser Nicole, Hugh-White Rupert, Arbet Jaron, Shemirani Ruhollah, Tian Mao, Thapaliya Prapti, Eloyan Lora, Chen Lawrence O, Lapinska Sandra, Ariannejad Maryam, Lajonchere Clara, Kenny Eimear E, Pasaniuc Bogdan, Bui Alex A T, Arboleda Valerie A, Chang Timothy S, Zaitlen Noah, Spellman Paul T, Boutros Paul C, Geschwind Daniel H

Abstract excerpt

Linking genetic data with electronic health records in hospital biobanks promises to advance precision medicine, but limited ancestral diversity constrains discovery and generalizability. We analyzed 93,936 participants from the UCLA ATLAS Community Health Initiative to inform disease prevalence and genetic risk across five continental and 36 fine-scale ancestry groups. We discovered numerous unreported...

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PMID: 41903539
DOI: 10.1016/j.cell.2026.03.007
PMCID: PMC13353064

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