Article

Chronic exposure to TNF reprograms cell signaling pathways in fibroblast-like synoviocytes by establishing long-term inflammatory memory

2020-06-27

Abstract excerpt

<h4>ABSTRACT</h4> Fibroblast-like synoviocytes (FLS) play a critical role in the pathogenesis of rheumatoid arthritis (RA). Chronic inflammation induces transcriptomic and epigenetic modifications that imparts a persistent catabolic phenotype to the FLS, despite their dissociation from the inflammatory environment. We analyzed high throughput gene expression and chromatin accessibility data from human and mouse F...

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Literature Corpus work: 7d562b59-04bc-5174-bdbb-5475a6dc1399
DOI: 10.1101/2020.06.27.171348

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