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Article

Prolonged Tumor Necrosis Factor α Primes Fibroblast‐like Synoviocytes in a Gene‐Specific Manner by Altering Chromatin

8 Sept 2014

Abstract excerpt

OBJECTIVE: During the course of rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) are chronically exposed to an inflammatory milieu. The purpose of this study was to test the hypothesis that prolonged exposure of FLS to tumor necrosis factor α (TNFα) augments inflammatory responses to secondary stimuli (priming effect). METHODS: FLS obtained from RA patients were exposed to TNFα for 3 days and were...

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PMID: 25199798
DOI: 10.1002/art.38871

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