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Article

Risk compensation after HIV-1 vaccination may accelerate viral adaptation and reduce cost-effectiveness: a modeling study

2020-12-14

Abstract excerpt

Pathogen populations can evolve in response to selective pressure from vaccine-induced immune responses. For HIV, models predict that viral adaptation, either via strain replacement or selection on de novo mutation, may rapidly reduce the effectiveness of an HIV vaccine. We hypothesized that behavioral risk compensation after vaccination may accelerate the transmission of vaccine resistant strains, increasing the...

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Literature Corpus work
7d4fe593-e298-53b5-8a43-3e2ac0b2041c
DOI
10.1101/2020.12.13.20248146
Open publication

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Risk compensation after HIV-1 vaccination may accelerate viral adaptation and reduce cost-effectiveness: a modeling studyDOI 10.1101/2020.12.13.20248146
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