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Adeno-associated viruses undergo substantial evolution in primates during natural infections

25 Apr 2003

Abstract excerpt

Adeno-associated viruses (AAVs) are single-stranded DNA viruses that are endemic in human populations without known clinical sequelae and are being evaluated as vectors for human gene therapy. To better understand the biology of this virus, we examined a number of nonhuman primate species for the presence of previously uncharacterized AAVs and characterized their structure and distribution. AAV genomes were...

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PMID: 12716974
DOI: 10.1073/pnas.0937739100

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