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Evolution of dependoparvoviruses across geological timescales—implications for design of AAV-based gene therapy vectors

19 May 2020

Abstract excerpt

Abstract Endogenous viral elements (EVEs) are genetic remnants of viruses that have integrated into host genomes millions of years ago and retained as heritable elements passed on to offspring until present-day. As a result, EVEs provide an opportunity to analyse the genomes of extinct viruses utilizing these genomic viral fossils to study evolution of viruses over large timescales. Analysis of sequences from...

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PMID: 32913662
DOI: 10.1093/ve/veaa043

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