Article

Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets

2024-09-04

Abstract excerpt

Matrigel/BME, a basement membrane-like preparation, supports long-term growth of epithelial 3D organoids from adult stem cells (ASC) 1,2 . Here, we show that interaction between Matrigel’s major component Laminin111 with epithelial α6β1-integrin is crucial for this process. The outer membrane protein Invasin of Yersinia is known to activate multiple integrin-β1 complexes, including integrin-α6β1. A C-terminal in...

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Literature Corpus work: 7d1dcd01-a157-546d-9279-837e7c13753a
DOI: 10.1101/2024.09.03.610788

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Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheetsDOI 10.1101/2024.09.03.610788Read

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