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OpenADMET: Embracing the Avoid-Ome to Transform Drug Discovery

2025-12-12

Abstract excerpt

Drug discovery faces significant obstacles posed by unpredictable pharmacokinetic and safety properties, necessitating a complex, multiparameter optimization process. ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) issues remain the primary reason for failure in drug development, with over 90% of discovery compounds failing basic ADME standards and unexpected ADMET problems causing around 30% of...

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Literature Corpus work
7d0d159d-626c-50ef-94c8-07996191896e
DOI
10.20944/preprints202512.1202.v1
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OpenADMET: Embracing the Avoid-Ome to Transform Drug DiscoveryDOI 10.20944/preprints202512.1202.v1
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