Article
ATP7A (Menkes protein) functions in axonal targeting and synaptogenesis.
Molecular and cellular neurosciences - 1 Mar 2007
El Meskini Rajaâ, Crabtree Kelli L, Cline Laura B, Mains Richard E, Eipper Betty A, Ronnett Gabriele V
Abstract excerpt
Menkes disease (MD) is a neurodegenerative disorder caused by mutations in the copper transporter, ATP7A, a P-type ATPase. We previously used the olfactory system to demonstrate that ATP7A expression is developmentally, not constitutive, regulated, peaking during synaptogenesis when it is highly expressed in extending axons in a copper-independent manner. Although not known to be associated with axonal functions,...
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